Science News Hub is here for everyone who loves discovering the latest in science and technology, no matter how much or how little you know about these fields. This website aims to enlighten you on a wide variety of topics, from understanding different diseases and where they come from, to sharing the newest breakthroughs in treatments. My goal is to make complicated scientific ideas easy to understand and to highlight the most exciting new research.
Metformin: A Drug with the Potential to Combat Aging
Metformin, a medication primarily used to manage type 2 diabetes, has emerged as a promising candidate in the field of ageing research. Studies suggest that metformin’s effects extend beyond blood sugar control, potentially influencing cellular pathways that regulate ageing and reducing the risk of age-related diseases such as cancer, cardiovascular disease, and neurodegenerative conditions.
2024 Nobel Prize in Physiology or Medicine
The 2024 Nobel Prize in Physiology or Medicine has been awarded jointly to American scientists Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) and its pivotal role in post-transcriptional gene regulation. This insight has significantly advanced our understanding of gene expression mechanisms in multicellular organisms, including humans.
NAD+, Sirtuins, and Their Role in Aging
Aging is a complex process influenced by many biological molecules and pathways that regulate cellular health, stress responses, and energy production. Among these, NAD+ (nicotinamide adenine dinucleotide) and a group of proteins called sirtuins have received significant attention for their roles in maintaining cellular function and promoting resilience against age-related decline. While they are not the only factors involved in aging, their interplay offers valuable insights into how our bodies manage the challenges of aging. This article explores the roles of NAD+ and sirtuins in aging and why they are essential for understanding longevity.
Understanding Breast Cancer: Causes, Types, and Treatments
Breast cancer is one of the most common cancers worldwide, affecting millions of people each year. Although it primarily impacts women, men can also develop the disease, though less frequently. The condition occurs when breast cells grow abnormally, often resulting in the formation of a lump or tumor. Recent advances in science have provided insights into the causes of breast cancer, leading to improved prevention strategies, early detection methods, and treatment options.
Telomers and Aging
Aging is a fundamental aspect of human biology, characterized by the gradual decline in physiological functions and increased susceptibility to diseases. While the concept of extending lifespan and improving health during aging remains a significant scientific challenge, understanding the biological mechanisms behind aging is crucial. One key factor in this process is the role of telomeres in our DNA.
Multifunctional Properties of Gold Nanoparticles and Their Role as Radiosensitisers
Gold nanoparticles (AuNPs) have gained considerable attention in cancer research due to their exceptional physical and chemical properties. Among their various applications, their role as radiosensitisers—agents that increase the sensitivity of cancer cells to radiation—stands out as particularly encouraging. This review discusses the multifunctional properties of AuNPs and their potential to revolutionise radiation therapy by enhancing its precision and effectiveness.
Breakthrough in Liver Disease Treatment: VEGFA mRNA-LNP Therapy
Liver diseases, particularly those involving chronic damage like steatosis and fibrosis, often have limited treatment options. However, a recent study published in Cell Stem Cell introduces a promising new therapy using VEGFA mRNA-LNP. This breakthrough treatment promotes the conversion of biliary epithelial cells into hepatocytes, aiding in liver regeneration and reversing both fat accumulation and tissue scarring.
Tyrosine Kinase Inhibitors: A Targeted Approach to Cancer Therapy
Cancer treatments have evolved significantly over the years, with targeted therapies now offering more precise ways to attack the disease. One such group of drugs is tyrosine kinase inhibitors (TKIs), which are used to treat various cancers by focusing on specific proteins that drive cancer growth.
UK Approves World's First CRISPR Gene-Editing Therapy Casgevy, Offering Groundbreaking Treatment for Sickle Cell Disease and Beta Thalassemia and Signaling a New Dawn in Genetic Medicine
How the Label “Cellular Debris” Slowed Down Exosome Research and Why It Matters Now
Exosomes are tiny vesicles secreted by cells, carrying molecules such as proteins, lipids, and RNA to communicate with other cells. Today, they are recognised as key players in health and disease, but for years, their importance was overlooked. This was largely due to being labelled as “cellular debris,” a term that suggested they were merely waste products with no real function. Here, we explore how this misunderstanding held back research, what exosomes truly are, and why they are now central to groundbreaking scientific discoveries.
Astrocytes, the star-shaped cells in the brain, have long been considered mere supporting players in the central nervous system (CNS). However, a burgeoning body of research has revealed that they are, in fact, key actors in both brain health and disease. This revelation is reshaping our understanding of neurological disorders and opening up new avenues for treatment.
The Gut Microbiota–Brain Axis
The gut microbiota, a complex community of microorganisms inhabiting the gastrointestinal tract, has emerged as a key player in regulating various physiological processes, including behavior and neurological health. The interplay between the gut microbiota and the brain, known as the gut–brain axis, is a bidirectional communication network involving neural, hormonal, and immunological pathways.
